Drug interactions
Bortezomib + Etrasimod
Severity: Major
Bortezomib and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and bortezomib is an antineoplastic with immunosuppressive effects. Together they may increase the risk of serious infection. The combination has not been formally studied.
What this interaction means in plain words
Bortezomib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from S1P receptor modulation (lymphocyte sequestration) plus proteasome inhibitor effects.
What to do
Avoid concurrent use where possible. If it is necessary, monitor closely for infection and check lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
- Bortezomib + Mitotane Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Bortezomib with Etrasimod?
MediHelp rates the interaction as major. Bortezomib and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and bortezomib is an antineoplastic with immunosuppressive effects. Together they may increase the risk of serious infection. The combination has not been formally studied.
How serious is the interaction between Bortezomib and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If it is necessary, monitor closely for infection and check lymphocyte counts.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Fosphenytoin. The full list is on the Bortezomib page.
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