Drug interactions
Bortezomib + Cannabidiol
Severity: Minor
Bortezomib and Cannabidiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and CYP3A4 and might raise bortezomib exposure, which could increase neuropathy, cytopenias and gastrointestinal effects. The effect has not been well characterized.
What this interaction means in plain words
Bortezomib and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bortezomib belongs to Oncology; Cannabidiol belongs to Central Nervous System.
Why it happens
Cannabidiol inhibits CYP2C19 and CYP3A4, which may reduce bortezomib clearance.
What to do
Monitor for peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity, and reduce the bortezomib dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Bortezomib with Cannabidiol?
MediHelp rates the interaction as minor. Bortezomib and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits CYP2C19 and CYP3A4 and might raise bortezomib exposure, which could increase neuropathy, cytopenias and gastrointestinal effects. The effect has not been well characterized.
How serious is the interaction between Bortezomib and Cannabidiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity, and reduce the bortezomib dose if toxicity occurs.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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