Drug interactions
Bortezomib + Cenobamate
Severity: Moderate
Bortezomib and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and inhibits CYP2C19, so its effect on bortezomib is mixed. The net effect may be reduced bortezomib exposure and efficacy, since CYP3A4 induction would probably dominate.
What this interaction means in plain words
Bortezomib and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4 and inhibits CYP2C19, which both contribute to bortezomib metabolism.
What to do
Monitor disease response and toxicity, and consider an alternative anticonvulsant if loss of efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Bortezomib with Cenobamate?
MediHelp rates the interaction as moderate. Bortezomib and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and inhibits CYP2C19, so its effect on bortezomib is mixed. The net effect may be reduced bortezomib exposure and efficacy, since CYP3A4 induction would probably dominate.
How serious is the interaction between Bortezomib and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease response and toxicity, and consider an alternative anticonvulsant if loss of efficacy is suspected.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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