Drug interactions
Bortezomib + Dabrafenib
Severity: Moderate
Bortezomib and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower bortezomib exposure, which could reduce antimyeloma effect. The effect is predicted from the mechanism and has not been documented in clinical studies.
What this interaction means in plain words
Bortezomib and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing the metabolism of bortezomib.
What to do
Monitor the response to bortezomib. Prefer an alternative to dabrafenib when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Bortezomib with Dabrafenib?
MediHelp rates the interaction as moderate. Bortezomib and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower bortezomib exposure, which could reduce antimyeloma effect. The effect is predicted from the mechanism and has not been documented in clinical studies.
How serious is the interaction between Bortezomib and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the response to bortezomib. Prefer an alternative to dabrafenib when feasible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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