Drug interactions
Bortezomib + Dichlorphenamide
Severity: Moderate
Bortezomib and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium wasting, and bortezomib can cause vomiting and diarrhea that further deplete potassium. Combined use may lead to hypokalemia and arrhythmia risk.
What this interaction means in plain words
Bortezomib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium loss through renal effects of carbonic anhydrase inhibition and gastrointestinal losses.
What to do
Monitor serum potassium regularly and replace potassium as needed, especially during diarrhea or vomiting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Bortezomib with Dichlorphenamide?
MediHelp rates the interaction as moderate. Bortezomib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes renal potassium wasting, and bortezomib can cause vomiting and diarrhea that further deplete potassium. Combined use may lead to hypokalemia and arrhythmia risk.
How serious is the interaction between Bortezomib and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and replace potassium as needed, especially during diarrhea or vomiting.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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