Drug interactions
Bortezomib + Diltiazem
Severity: Moderate
Bortezomib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase bortezomib exposure, potentially worsening neuropathy, cytopenias and gastrointestinal effects. Both can cause hypotension.
What this interaction means in plain words
Bortezomib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4, which contributes to bortezomib metabolism, with additive hypotensive effects.
What to do
Monitor for bortezomib toxicity and blood pressure, and reduce the bortezomib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Diltiazem?
MediHelp rates the interaction as moderate. Bortezomib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase bortezomib exposure, potentially worsening neuropathy, cytopenias and gastrointestinal effects. Both can cause hypotension.
How serious is the interaction between Bortezomib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bortezomib toxicity and blood pressure, and reduce the bortezomib dose if adverse effects emerge.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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