Drug interactions
Bortezomib + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Bortezomib and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bortezomib is partly metabolized by CYP3A4, and cobicistat inhibits this enzyme, which may raise bortezomib exposure. This could increase peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
What this interaction means in plain words
Bortezomib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing the metabolic clearance of bortezomib.
What to do
Monitor for neuropathy, cytopenias and gastrointestinal toxicity, and reduce or hold the bortezomib dose if toxicity develops. Consider an unboosted antiretroviral regimen if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Bortezomib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bortezomib is partly metabolized by CYP3A4, and cobicistat inhibits this enzyme, which may raise bortezomib exposure. This could increase peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity.
How serious is the interaction between Bortezomib and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, cytopenias and gastrointestinal toxicity, and reduce or hold the bortezomib dose if toxicity develops. Consider an unboosted antiretroviral regimen if feasible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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