Drug interactions
Bortezomib + Fexinidazole
Severity: Moderate
Bortezomib and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites can inhibit CYP3A4, which may raise bortezomib exposure. Higher levels could worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity. Fexinidazole also prolongs the QT interval, and few clinical data exist.
What this interaction means in plain words
Bortezomib and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing bortezomib metabolism.
What to do
Avoid if an alternative is available; otherwise monitor for neuropathy and cytopenias and consider reducing the bortezomib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Fexinidazole?
MediHelp rates the interaction as moderate. Bortezomib and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites can inhibit CYP3A4, which may raise bortezomib exposure. Higher levels could worsen peripheral neuropathy, thrombocytopenia and gastrointestinal toxicity. Fexinidazole also prolongs the QT interval, and few clinical data exist.
How serious is the interaction between Bortezomib and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available; otherwise monitor for neuropathy and cytopenias and consider reducing the bortezomib dose.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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