Drug interactions
Bortezomib + Indinavir
Severity: Moderate
Bortezomib and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and may raise bortezomib exposure. Higher levels could increase the risk of peripheral neuropathy, thrombocytopenia, gastrointestinal toxicity and hypotension.
What this interaction means in plain words
Bortezomib and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4, which contributes to bortezomib metabolism, reducing its clearance.
What to do
Monitor closely for bortezomib toxicity, particularly neuropathy and cytopenias, and consider reducing the bortezomib dose if adverse effects emerge. Consider an alternative antiretroviral if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Indinavir?
MediHelp rates the interaction as moderate. Bortezomib and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and may raise bortezomib exposure. Higher levels could increase the risk of peripheral neuropathy, thrombocytopenia, gastrointestinal toxicity and hypotension.
How serious is the interaction between Bortezomib and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bortezomib toxicity, particularly neuropathy and cytopenias, and consider reducing the bortezomib dose if adverse effects emerge. Consider an alternative antiretroviral if feasible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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