Drug interactions
Bortezomib + Isoniazid
Severity: Moderate
Bortezomib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid could slightly raise bortezomib exposure via CYP3A4 inhibition, and both drugs can cause peripheral neuropathy. The additive neurotoxicity is the more clinically relevant concern.
What this interaction means in plain words
Bortezomib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bortezomib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Additive neurotoxicity, plus weak CYP3A4 inhibition by isoniazid possibly raising bortezomib levels.
What to do
Give pyridoxine with isoniazid and assess regularly for peripheral neuropathy. Reduce or hold bortezomib per labeling if neuropathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Isoniazid?
MediHelp rates the interaction as moderate. Bortezomib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid could slightly raise bortezomib exposure via CYP3A4 inhibition, and both drugs can cause peripheral neuropathy. The additive neurotoxicity is the more clinically relevant concern.
How serious is the interaction between Bortezomib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pyridoxine with isoniazid and assess regularly for peripheral neuropathy. Reduce or hold bortezomib per labeling if neuropathy develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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