Drug interactions
Bosentan + Clonazepam
Severity: Minor
Bosentan and Clonazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower clonazepam concentrations, potentially reducing its anticonvulsant or anxiolytic effect. The clinical impact is expected to be modest and variable.
What this interaction means in plain words
Bosentan and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Clonazepam belongs to Central Nervous System.
Why it happens
Bosentan induction of CYP3A4 increases clonazepam metabolism.
What to do
Monitor for loss of clonazepam effect, such as breakthrough seizures, after starting bosentan. Increase the clonazepam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Clonazepam?
MediHelp rates the interaction as minor. Bosentan and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and may lower clonazepam concentrations, potentially reducing its anticonvulsant or anxiolytic effect. The clinical impact is expected to be modest and variable.
How serious is the interaction between Bosentan and Clonazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clonazepam effect, such as breakthrough seizures, after starting bosentan. Increase the clonazepam dose if needed.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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