Drug interactions
Bosentan + Dexamethasone
Severity: Moderate
Bosentan and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower dexamethasone exposure, potentially reducing its effect. Bosentan levels might also be reduced by dexamethasone induction.
What this interaction means in plain words
Bosentan and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Dexamethasone belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and CYP2C9) by bosentan increases dexamethasone clearance.
What to do
Monitor clinical response to dexamethasone and increase the dose if the therapeutic effect is inadequate; monitor pulmonary hypertension response to bosentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Dexamethasone?
MediHelp rates the interaction as moderate. Bosentan and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower dexamethasone exposure, potentially reducing its effect. Bosentan levels might also be reduced by dexamethasone induction.
How serious is the interaction between Bosentan and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to dexamethasone and increase the dose if the therapeutic effect is inadequate; monitor pulmonary hypertension response to bosentan.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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