Drug interactions
Bosentan + Diazepam
Severity: Minor
Bosentan and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9 and may lower diazepam exposure, potentially reducing its anxiolytic or anticonvulsant effect. The magnitude is not well defined and is likely modest.
What this interaction means in plain words
Bosentan and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Diazepam belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 (and CYP2C9) by bosentan increasing diazepam metabolism.
What to do
Monitor for reduced diazepam efficacy and increase the dose if needed. Reassess dose if bosentan is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Diazepam?
MediHelp rates the interaction as minor. Bosentan and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and CYP2C9 and may lower diazepam exposure, potentially reducing its anxiolytic or anticonvulsant effect. The magnitude is not well defined and is likely modest.
How serious is the interaction between Bosentan and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diazepam efficacy and increase the dose if needed. Reassess dose if bosentan is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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