Drug interactions
Bosentan + Fesoterodine
Severity: Minor
Bosentan and Fesoterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower exposure to 5-hydroxymethyl tolterodine, the active metabolite of fesoterodine. Reduced antimuscarinic effect may lead to poorer control of overactive bladder symptoms.
What this interaction means in plain words
Bosentan and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Fesoterodine belongs to Genitourinary.
Why it happens
Bosentan induces CYP3A4, increasing metabolic clearance of the active metabolite of fesoterodine.
What to do
No dose change is routinely needed; assess symptom control and increase the fesoterodine dose within the labeled range if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Fesoterodine?
MediHelp rates the interaction as minor. Bosentan and Fesoterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a moderate CYP3A4 inducer and may lower exposure to 5-hydroxymethyl tolterodine, the active metabolite of fesoterodine. Reduced antimuscarinic effect may lead to poorer control of overactive bladder symptoms.
How serious is the interaction between Bosentan and Fesoterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; assess symptom control and increase the fesoterodine dose within the labeled range if efficacy is inadequate.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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