Drug interactions
Bosentan + Galantamine
Severity: Minor
Bosentan and Galantamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4, which is one of the pathways of galantamine metabolism, so galantamine exposure may fall slightly. The effect is expected to be small.
What this interaction means in plain words
Bosentan and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Galantamine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by bosentan increases galantamine clearance.
What to do
No routine adjustment is needed. Reassess cognitive response and titrate galantamine if benefit decreases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Galantamine?
MediHelp rates the interaction as minor. Bosentan and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4, which is one of the pathways of galantamine metabolism, so galantamine exposure may fall slightly. The effect is expected to be small.
How serious is the interaction between Bosentan and Galantamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess cognitive response and titrate galantamine if benefit decreases.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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