Drug interactions
Bosentan + Glasdegib
Severity: Moderate
Bosentan and Glasdegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce glasdegib exposure and lessen its efficacy in acute myeloid leukemia. Labeling advises avoiding strong CYP3A inducers, and moderate inducers such as bosentan carry a smaller risk.
What this interaction means in plain words
Bosentan and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Glasdegib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, which metabolizes glasdegib.
What to do
Avoid strong inducers; with bosentan monitor for loss of response. If a moderate inducer is required, consider increasing the glasdegib dose according to labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Bosentan with Glasdegib?
MediHelp rates the interaction as moderate. Bosentan and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce glasdegib exposure and lessen its efficacy in acute myeloid leukemia. Labeling advises avoiding strong CYP3A inducers, and moderate inducers such as bosentan carry a smaller risk.
How serious is the interaction between Bosentan and Glasdegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong inducers; with bosentan monitor for loss of response. If a moderate inducer is required, consider increasing the glasdegib dose according to labeling.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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