Drug interactions
Bosentan + Ibuprofen
Severity: Minor
Bosentan and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP2C9 and CYP3A4, so it may modestly reduce ibuprofen exposure. NSAIDs may also promote fluid retention in patients on bosentan.
What this interaction means in plain words
Bosentan and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Ibuprofen belongs to Musculoskeletal.
Why it happens
Induction of CYP2C9 by bosentan increases ibuprofen metabolism.
What to do
No dose change is typically required. Monitor analgesic response and watch for edema or weight gain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ibuprofen?
MediHelp rates the interaction as minor. Bosentan and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP2C9 and CYP3A4, so it may modestly reduce ibuprofen exposure. NSAIDs may also promote fluid retention in patients on bosentan.
How serious is the interaction between Bosentan and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required. Monitor analgesic response and watch for edema or weight gain.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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