Drug interactions
Bosentan + Ifosfamide
Severity: Moderate
Bosentan and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may induce enzymes that activate and break down ifosfamide, which can shift exposure toward active alkylating metabolites and the neurotoxic and nephrotoxic metabolite chloroacetaldehyde. This could increase toxicity or alter efficacy.
What this interaction means in plain words
Bosentan and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Ifosfamide belongs to Oncology.
Why it happens
Bosentan is a CYP3A4 and CYP2C9 inducer that may increase ifosfamide metabolism including the chloroacetaldehyde pathway.
What to do
Monitor for neurotoxicity, renal toxicity and myelosuppression, and consider ifosfamide dose adjustment if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Ifosfamide?
MediHelp rates the interaction as moderate. Bosentan and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may induce enzymes that activate and break down ifosfamide, which can shift exposure toward active alkylating metabolites and the neurotoxic and nephrotoxic metabolite chloroacetaldehyde. This could increase toxicity or alter efficacy.
How serious is the interaction between Bosentan and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neurotoxicity, renal toxicity and myelosuppression, and consider ifosfamide dose adjustment if toxicity appears.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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