Drug interactions
Bosentan + Istradefylline
Severity: Moderate
Bosentan and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower istradefylline levels and reduce its benefit in Parkinson disease. Strong inducers are to be avoided and moderate inducers carry a smaller risk.
What this interaction means in plain words
Bosentan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Istradefylline belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, which metabolizes istradefylline.
What to do
Monitor for worsening motor symptoms (OFF time). Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Bosentan with Istradefylline?
MediHelp rates the interaction as moderate. Bosentan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower istradefylline levels and reduce its benefit in Parkinson disease. Strong inducers are to be avoided and moderate inducers carry a smaller risk.
How serious is the interaction between Bosentan and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening motor symptoms (OFF time). Adjust therapy if efficacy is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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