Drug interactions
Bosentan + Lefamulin
Severity: Moderate
Bosentan and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce lefamulin exposure and risk treatment failure in community-acquired pneumonia. Labeling advises avoiding moderate or strong CYP3A inducers unless benefit outweighs risk.
What this interaction means in plain words
Bosentan and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Lefamulin belongs to Anti Bacterial.
Why it happens
Bosentan induces CYP3A4, increasing lefamulin metabolism.
What to do
Consider an alternative antibiotic. If used, monitor for clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Bosentan with Lefamulin?
MediHelp rates the interaction as moderate. Bosentan and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce lefamulin exposure and risk treatment failure in community-acquired pneumonia. Labeling advises avoiding moderate or strong CYP3A inducers unless benefit outweighs risk.
How serious is the interaction between Bosentan and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic. If used, monitor for clinical response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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