Drug interactions
Bosentan + Mavacamten
Severity: Major
Bosentan and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan as a moderate CYP3A4 inducer, along with CYP2C19 effects, may lower mavacamten levels and reduce its efficacy in obstructive hypertrophic cardiomyopathy.
What this interaction means in plain words
Bosentan and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Mavacamten belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 and CYP2C19 by bosentan increases mavacamten clearance.
What to do
Avoid the combination where possible; if used, monitor LVOT gradient and LVEF with echocardiography and adjust the mavacamten dose accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Bosentan with Mavacamten?
MediHelp rates the interaction as major. Bosentan and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan as a moderate CYP3A4 inducer, along with CYP2C19 effects, may lower mavacamten levels and reduce its efficacy in obstructive hypertrophic cardiomyopathy.
How serious is the interaction between Bosentan and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor LVOT gradient and LVEF with echocardiography and adjust the mavacamten dose accordingly.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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