Drug interactions
Bosentan + Metformin-pioglitazone
Severity: Minor
Bosentan and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a modest enzyme inducer and may lower pioglitazone exposure, potentially weakening glycemic control. Bosentan can also cause fluid retention, which may add to the edema risk of pioglitazone.
What this interaction means in plain words
Bosentan and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Induction of hepatic CYP enzymes increases pioglitazone clearance; additive fluid retention is pharmacodynamic.
What to do
Monitor blood glucose and signs of fluid retention or heart failure, and adjust pioglitazone if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Bosentan and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a modest enzyme inducer and may lower pioglitazone exposure, potentially weakening glycemic control. Bosentan can also cause fluid retention, which may add to the edema risk of pioglitazone.
How serious is the interaction between Bosentan and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of fluid retention or heart failure, and adjust pioglitazone if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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