Drug interactions
Bosentan + Nateglinide
Severity: Minor
Bosentan and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a modest inducer of CYP2C9 and CYP3A4, which may modestly lower nateglinide concentrations. The result could be reduced post-meal glucose control, though the effect is likely small.
What this interaction means in plain words
Bosentan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Nateglinide belongs to Endocrine.
Why it happens
Bosentan induces CYP2C9 and CYP3A4, increasing the metabolism of nateglinide.
What to do
No empirical dose change is needed. Check glucose control when bosentan is started or stopped and adjust nateglinide if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Nateglinide?
MediHelp rates the interaction as minor. Bosentan and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan is a modest inducer of CYP2C9 and CYP3A4, which may modestly lower nateglinide concentrations. The result could be reduced post-meal glucose control, though the effect is likely small.
How serious is the interaction between Bosentan and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Check glucose control when bosentan is started or stopped and adjust nateglinide if needed.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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