Drug interactions
Bosentan + Oxcarbazepine
Severity: Moderate
Bosentan and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower bosentan concentrations, potentially reducing control of pulmonary arterial hypertension. Bosentan is itself a CYP3A4 and CYP2C9 substrate and inducer, so net effects are variable.
What this interaction means in plain words
Bosentan and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing bosentan metabolism.
What to do
Monitor clinical response and functional status in pulmonary hypertension. Adjust bosentan therapy if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Oxcarbazepine?
MediHelp rates the interaction as moderate. Bosentan and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower bosentan concentrations, potentially reducing control of pulmonary arterial hypertension. Bosentan is itself a CYP3A4 and CYP2C9 substrate and inducer, so net effects are variable.
How serious is the interaction between Bosentan and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and functional status in pulmonary hypertension. Adjust bosentan therapy if efficacy declines.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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