Drug interactions
Bosentan + Palovarotene
Severity: Moderate
Bosentan and Palovarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is metabolized mainly by CYP3A4, so induction by bosentan may lower its exposure and reduce its effect in fibrodysplasia ossificans progressiva.
What this interaction means in plain words
Bosentan and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Palovarotene belongs to Miscellaneous.
Why it happens
Bosentan induces CYP3A4, increasing palovarotene clearance.
What to do
Avoid the combination if possible. Otherwise monitor for reduced clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Bosentan with Palovarotene?
MediHelp rates the interaction as moderate. Bosentan and Palovarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palovarotene is metabolized mainly by CYP3A4, so induction by bosentan may lower its exposure and reduce its effect in fibrodysplasia ossificans progressiva.
How serious is the interaction between Bosentan and Palovarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. Otherwise monitor for reduced clinical response.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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