Drug interactions
Bosentan + Pazopanib
Severity: Moderate
Bosentan and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may lower pazopanib concentrations. Pazopanib is also hepatotoxic and bosentan carries hepatotoxicity risk, so combined liver injury is a concern.
What this interaction means in plain words
Bosentan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing pazopanib clearance, plus additive hepatotoxicity.
What to do
Monitor liver enzymes closely and watch for loss of pazopanib response. Prefer an alternative to bosentan if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Pazopanib?
MediHelp rates the interaction as moderate. Bosentan and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and may lower pazopanib concentrations. Pazopanib is also hepatotoxic and bosentan carries hepatotoxicity risk, so combined liver injury is a concern.
How serious is the interaction between Bosentan and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and watch for loss of pazopanib response. Prefer an alternative to bosentan if feasible.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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