Drug interactions
Bosentan + Pioglitazone
Severity: Minor
Bosentan and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and CYP2C9, which may modestly lower pioglitazone exposure. Pioglitazone is mainly metabolized by CYP2C8, so the effect is likely small, though glycemic control could be reduced.
What this interaction means in plain words
Bosentan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Pioglitazone belongs to Endocrine.
Why it happens
Induction of hepatic and intestinal cytochrome P450 enzymes increases pioglitazone clearance.
What to do
Monitor glucose and HbA1c after bosentan is started or stopped. Increase the pioglitazone dose only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Pioglitazone?
MediHelp rates the interaction as minor. Bosentan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and CYP2C9, which may modestly lower pioglitazone exposure. Pioglitazone is mainly metabolized by CYP2C8, so the effect is likely small, though glycemic control could be reduced.
How serious is the interaction between Bosentan and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after bosentan is started or stopped. Increase the pioglitazone dose only if control worsens.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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