Drug interactions
Bosentan + Pitolisant
Severity: Moderate
Bosentan and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant is cleared partly by CYP3A4, and inducers reduce its exposure, which may lessen its effect on wakefulness. Bosentan is a moderate rather than strong inducer, so the reduction is likely smaller than that seen with strong inducers.
What this interaction means in plain words
Bosentan and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Pitolisant belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, accelerating pitolisant metabolism.
What to do
Monitor for reduced efficacy of pitolisant and increase the dose within the labeled range if needed. Reassess the dose if bosentan is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Bosentan with Pitolisant?
MediHelp rates the interaction as moderate. Bosentan and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant is cleared partly by CYP3A4, and inducers reduce its exposure, which may lessen its effect on wakefulness. Bosentan is a moderate rather than strong inducer, so the reduction is likely smaller than that seen with strong inducers.
How serious is the interaction between Bosentan and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of pitolisant and increase the dose within the labeled range if needed. Reassess the dose if bosentan is stopped.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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