Drug interactions
Bosentan + Praziquantel
Severity: Moderate
Bosentan and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce praziquantel concentrations and potentially lead to treatment failure. The effect is predicted from its CYP3A4 induction.
What this interaction means in plain words
Bosentan and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Praziquantel belongs to Anti Parasitic.
Why it happens
Bosentan induces CYP3A4, accelerating praziquantel clearance.
What to do
Monitor for parasitological response, and consider repeat treatment if cure is not achieved. Bosentan generally cannot be interrupted, so specialist input on dosing may be needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Praziquantel?
MediHelp rates the interaction as moderate. Bosentan and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce praziquantel concentrations and potentially lead to treatment failure. The effect is predicted from its CYP3A4 induction.
How serious is the interaction between Bosentan and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for parasitological response, and consider repeat treatment if cure is not achieved. Bosentan generally cannot be interrupted, so specialist input on dosing may be needed.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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