Drug interactions
Bosentan + Sotorasib
Severity: Moderate
Bosentan and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower sotorasib plasma concentrations. This could reduce efficacy in KRAS G12C-mutated cancer.
What this interaction means in plain words
Bosentan and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Sotorasib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, accelerating sotorasib metabolism.
What to do
Avoid coadministration where possible, as labeling advises against strong CYP3A4 inducers and moderate inducers also reduce exposure. Monitor tumor response if unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Bosentan with Sotorasib?
MediHelp rates the interaction as moderate. Bosentan and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower sotorasib plasma concentrations. This could reduce efficacy in KRAS G12C-mutated cancer.
How serious is the interaction between Bosentan and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible, as labeling advises against strong CYP3A4 inducers and moderate inducers also reduce exposure. Monitor tumor response if unavoidable.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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