Drug interactions
Bosentan + Sunitinib
Severity: Moderate
Bosentan and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a CYP3A4 inducer and may reduce sunitinib and its active metabolite exposure. This may lower efficacy of sunitinib.
What this interaction means in plain words
Bosentan and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Sunitinib belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing sunitinib clearance.
What to do
Prefer an alternative to bosentan where possible. If used together, monitor response and consider sunitinib dose increase per labeling guidance for CYP3A4 inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Sunitinib?
MediHelp rates the interaction as moderate. Bosentan and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a CYP3A4 inducer and may reduce sunitinib and its active metabolite exposure. This may lower efficacy of sunitinib.
How serious is the interaction between Bosentan and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to bosentan where possible. If used together, monitor response and consider sunitinib dose increase per labeling guidance for CYP3A4 inducers.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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