Drug interactions
Bosentan + Tolterodine
Severity: Minor
Bosentan and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and may reduce tolterodine concentrations. The effect on the active moiety is likely small because CYP2D6 remains the main pathway in most patients.
What this interaction means in plain words
Bosentan and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Bosentan induction of CYP3A4 increases tolterodine metabolism.
What to do
No routine adjustment. Check symptom control and titrate tolterodine if efficacy decreases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Bosentan with Tolterodine?
MediHelp rates the interaction as minor. Bosentan and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan induces CYP3A4 and may reduce tolterodine concentrations. The effect on the active moiety is likely small because CYP2D6 remains the main pathway in most patients.
How serious is the interaction between Bosentan and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment. Check symptom control and titrate tolterodine if efficacy decreases.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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