Drug interactions
Bosentan + Trabectedin
Severity: Moderate
Bosentan and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce trabectedin exposure through CYP3A4 induction. Efficacy may decrease, though the clinical impact is uncertain.
What this interaction means in plain words
Bosentan and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Trabectedin belongs to Oncology.
Why it happens
Bosentan induces CYP3A4, increasing trabectedin clearance.
What to do
Avoid the combination where possible, as trabectedin labeling advises against strong CYP3A inducers. Monitor tumor response and toxicity if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Bosentan with Trabectedin?
MediHelp rates the interaction as moderate. Bosentan and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce trabectedin exposure through CYP3A4 induction. Efficacy may decrease, though the clinical impact is uncertain.
How serious is the interaction between Bosentan and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as trabectedin labeling advises against strong CYP3A inducers. Monitor tumor response and toxicity if used.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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