Drug interactions
Bosentan + Zuranolone
Severity: Moderate
Bosentan and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower zuranolone concentrations by inducing its CYP3A4-mediated metabolism. Reduced exposure could lead to loss of antidepressant effect in postpartum depression.
What this interaction means in plain words
Bosentan and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Zuranolone belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, which is the main metabolic pathway of zuranolone.
What to do
Avoid coadministration where possible, or monitor for reduced antidepressant response and consider a higher zuranolone dose only if supported by labeling. Reassess after bosentan changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Bosentan with Zuranolone?
MediHelp rates the interaction as moderate. Bosentan and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower zuranolone concentrations by inducing its CYP3A4-mediated metabolism. Reduced exposure could lead to loss of antidepressant effect in postpartum depression.
How serious is the interaction between Bosentan and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible, or monitor for reduced antidepressant response and consider a higher zuranolone dose only if supported by labeling. Reassess after bosentan changes.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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