Drug interactions
Bosutinib + Daunorubicin
Severity: Moderate
Bosutinib and Daunorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein, which transports daunorubicin. Increased daunorubicin exposure may enhance myelosuppression and cardiotoxicity, and bosutinib itself causes cytopenias.
What this interaction means in plain words
Bosutinib and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Daunorubicin belongs to Oncology.
Why it happens
P-glycoprotein inhibition by bosutinib and additive myelosuppression.
What to do
Monitor complete blood counts and cardiac function, and watch cumulative anthracycline dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bosutinib and Daunorubicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Daunorubicin?
MediHelp rates the interaction as moderate. Bosutinib and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein, which transports daunorubicin. Increased daunorubicin exposure may enhance myelosuppression and cardiotoxicity, and bosutinib itself causes cytopenias.
How serious is the interaction between Bosutinib and Daunorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and cardiac function, and watch cumulative anthracycline dose.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
