Drug interactions
Bosutinib + Dexamethasone
Severity: Moderate
Bosutinib and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone may lower bosutinib plasma concentrations through CYP3A4 induction. Reduced exposure can compromise control of chronic myeloid leukemia.
What this interaction means in plain words
Bosutinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Dexamethasone belongs to Endocrine.
Why it happens
Dexamethasone induces CYP3A4, increasing the metabolism of bosutinib, a CYP3A4 substrate.
What to do
Prefer a non-inducing corticosteroid alternative if feasible, and monitor molecular and hematologic response if dexamethasone is required. Avoid strong inducers with bosutinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Dexamethasone?
MediHelp rates the interaction as moderate. Bosutinib and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone may lower bosutinib plasma concentrations through CYP3A4 induction. Reduced exposure can compromise control of chronic myeloid leukemia.
How serious is the interaction between Bosutinib and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing corticosteroid alternative if feasible, and monitor molecular and hematologic response if dexamethasone is required. Avoid strong inducers with bosutinib.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.
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