Drug interactions
Bosutinib + Dipyridamole
Severity: Moderate
Bosutinib and Dipyridamole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipyridamole inhibits P-glycoprotein and may raise bosutinib exposure, increasing gastrointestinal and hepatic toxicity. The effect is predicted rather than well documented.
What this interaction means in plain words
Bosutinib and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Dipyridamole belongs to Cardiovascular.
Why it happens
Dipyridamole inhibits P-glycoprotein efflux of bosutinib, potentially increasing its exposure.
What to do
Monitor for diarrhea and liver enzyme elevations and reduce the bosutinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Dipyridamole?
MediHelp rates the interaction as moderate. Bosutinib and Dipyridamole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dipyridamole inhibits P-glycoprotein and may raise bosutinib exposure, increasing gastrointestinal and hepatic toxicity. The effect is predicted rather than well documented.
How serious is the interaction between Bosutinib and Dipyridamole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and liver enzyme elevations and reduce the bosutinib dose if toxicity develops.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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