Drug interactions
Bosutinib + Docetaxel
Severity: Moderate
Bosutinib and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein in vitro and may modestly raise docetaxel exposure. Both drugs can also cause myelosuppression.
What this interaction means in plain words
Bosutinib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Docetaxel belongs to Oncology.
Why it happens
Possible inhibition of P-glycoprotein efflux of docetaxel plus additive myelosuppression.
What to do
Monitor complete blood counts and docetaxel toxicity. Reduce the dose if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Docetaxel?
MediHelp rates the interaction as moderate. Bosutinib and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein in vitro and may modestly raise docetaxel exposure. Both drugs can also cause myelosuppression.
How serious is the interaction between Bosutinib and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and docetaxel toxicity. Reduce the dose if severe neutropenia occurs.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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