Drug interactions
Bosutinib + Erythromycin
Severity: Major
Bosutinib and Erythromycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin can increase bosutinib concentrations, raising the risk of gastrointestinal, hepatic and other dose-related toxicities. Bosutinib labeling advises avoiding moderate CYP3A and P-gp inhibitors.
What this interaction means in plain words
Bosutinib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of bosutinib by erythromycin.
What to do
Use an alternative antibiotic that does not inhibit CYP3A4 or P-gp. If unavoidable, monitor closely for bosutinib toxicity and consider dose reduction.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Erythromycin?
MediHelp rates the interaction as major. Bosutinib and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin can increase bosutinib concentrations, raising the risk of gastrointestinal, hepatic and other dose-related toxicities. Bosutinib labeling advises avoiding moderate CYP3A and P-gp inhibitors.
How serious is the interaction between Bosutinib and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic that does not inhibit CYP3A4 or P-gp. If unavoidable, monitor closely for bosutinib toxicity and consider dose reduction.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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