Drug interactions
Bosutinib + Irinotecan
Severity: Moderate
Bosutinib and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein and may increase irinotecan exposure. Both drugs cause diarrhea and myelosuppression, so toxicity may be additive.
What this interaction means in plain words
Bosutinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
P-gp inhibition by bosutinib plus overlapping gastrointestinal and hematologic toxicity.
What to do
Monitor for diarrhea and neutropenia, giving prompt antidiarrheal treatment and reducing the irinotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Irinotecan?
MediHelp rates the interaction as moderate. Bosutinib and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein and may increase irinotecan exposure. Both drugs cause diarrhea and myelosuppression, so toxicity may be additive.
How serious is the interaction between Bosutinib and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea and neutropenia, giving prompt antidiarrheal treatment and reducing the irinotecan dose if toxicity occurs.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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