Drug interactions
Bosutinib + Lidocaine
Severity: Minor
Bosutinib and Lidocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 inhibitor and bosutinib is a CYP3A4 substrate, so bosutinib exposure could rise slightly. Systemic lidocaine, especially topical or local use, is unlikely to cause a meaningful change.
What this interaction means in plain words
Bosutinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Lidocaine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated bosutinib metabolism.
What to do
No dose change is generally needed; monitor for bosutinib adverse effects such as diarrhea and liver enzyme elevation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Lidocaine?
MediHelp rates the interaction as minor. Bosutinib and Lidocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 inhibitor and bosutinib is a CYP3A4 substrate, so bosutinib exposure could rise slightly. Systemic lidocaine, especially topical or local use, is unlikely to cause a meaningful change.
How serious is the interaction between Bosutinib and Lidocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for bosutinib adverse effects such as diarrhea and liver enzyme elevation as usual.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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