Drug interactions
Bosutinib + Pazopanib
Severity: Moderate
Bosutinib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein and may increase pazopanib exposure. Both drugs are also associated with hepatotoxicity and QT effects, adding to the concern.
What this interaction means in plain words
Bosutinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
P-gp inhibition by bosutinib increases pazopanib bioavailability, with overlapping hepatotoxic effects.
What to do
Monitor liver function tests regularly and consider ECG monitoring. Reduce the dose of either drug if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Pazopanib?
MediHelp rates the interaction as moderate. Bosutinib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib inhibits P-glycoprotein and may increase pazopanib exposure. Both drugs are also associated with hepatotoxicity and QT effects, adding to the concern.
How serious is the interaction between Bosutinib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly and consider ECG monitoring. Reduce the dose of either drug if transaminases rise.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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