Drug interactions
Bosutinib + Sunitinib
Severity: Moderate
Bosutinib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are kinase inhibitors with overlapping toxicities including QT effects, hepatotoxicity and GI adverse events. Sunitinib may raise bosutinib exposure by inhibiting efflux transporters.
What this interaction means in plain words
Bosutinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition plus additive toxicity.
What to do
Monitor liver enzymes, ECG and tolerability, and reduce the dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Sunitinib?
MediHelp rates the interaction as moderate. Bosutinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are kinase inhibitors with overlapping toxicities including QT effects, hepatotoxicity and GI adverse events. Sunitinib may raise bosutinib exposure by inhibiting efflux transporters.
How serious is the interaction between Bosutinib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, ECG and tolerability, and reduce the dose if toxicity develops.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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