Drug interactions
Bosutinib + Tamoxifen
Severity: Moderate
Bosutinib and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen may inhibit P-gp and increase bosutinib exposure, possibly increasing gastrointestinal, hepatic and myelosuppressive toxicity.
What this interaction means in plain words
Bosutinib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Tamoxifen belongs to Endocrine.
Why it happens
Tamoxifen inhibits P-gp efflux of bosutinib.
What to do
Monitor liver enzymes, blood counts and GI tolerance; reduce bosutinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Tamoxifen?
MediHelp rates the interaction as moderate. Bosutinib and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen may inhibit P-gp and increase bosutinib exposure, possibly increasing gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, blood counts and GI tolerance; reduce bosutinib dose if toxicity occurs.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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