Drug interactions
Bosutinib + Tetracycline
Severity: Minor
Bosutinib and Tetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline is not an established clinically relevant CYP3A4 inhibitor, so a substantial increase in bosutinib exposure is unlikely. The concern is theoretical and extrapolated from the class of CYP3A inhibitors.
What this interaction means in plain words
Bosutinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible weak CYP3A4 inhibition; not well established for tetracycline.
What to do
No empiric dose change is needed; monitor for bosutinib gastrointestinal, hepatic and hematologic toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Tetracycline?
MediHelp rates the interaction as minor. Bosutinib and Tetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline is not an established clinically relevant CYP3A4 inhibitor, so a substantial increase in bosutinib exposure is unlikely. The concern is theoretical and extrapolated from the class of CYP3A inhibitors.
How serious is the interaction between Bosutinib and Tetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for bosutinib gastrointestinal, hepatic and hematologic toxicity as usual.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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