Drug interactions
Bosutinib + Tolvaptan
Severity: Moderate
Bosutinib and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and may raise exposure to bosutinib, which is a P-gp substrate. Higher bosutinib levels could increase gastrointestinal, hepatic and myelosuppressive toxicity.
What this interaction means in plain words
Bosutinib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan inhibits P-glycoprotein efflux, reducing bosutinib efflux and increasing its exposure.
What to do
Monitor for bosutinib adverse effects, including diarrhea, liver enzymes and blood counts. Reduce the bosutinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Tolvaptan?
MediHelp rates the interaction as moderate. Bosutinib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan inhibits P-glycoprotein and may raise exposure to bosutinib, which is a P-gp substrate. Higher bosutinib levels could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bosutinib adverse effects, including diarrhea, liver enzymes and blood counts. Reduce the bosutinib dose if toxicity develops.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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