Drug interactions
Bremelanotide + Methotrexate
Severity: Minor
Bremelanotide and Methotrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may delay gastric emptying and thereby slow or reduce absorption of oral drugs. Oral methotrexate absorption could be altered, but a clinically meaningful effect on methotrexate efficacy is not established, particularly at low weekly doses.
What this interaction means in plain words
Bremelanotide and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bremelanotide belongs to Genitourinary; Methotrexate belongs to Oncology.
Why it happens
Delayed gastric emptying from bremelanotide may alter the rate and extent of oral methotrexate absorption.
What to do
No routine change is needed; monitor clinical response to oral methotrexate. Consider parenteral methotrexate if loss of efficacy is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporin Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
Frequently asked questions
Can I take Bremelanotide with Methotrexate?
MediHelp rates the interaction as minor. Bremelanotide and Methotrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bremelanotide may delay gastric emptying and thereby slow or reduce absorption of oral drugs. Oral methotrexate absorption could be altered, but a clinically meaningful effect on methotrexate efficacy is not established, particularly at low weekly doses.
How serious is the interaction between Bremelanotide and Methotrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor clinical response to oral methotrexate. Consider parenteral methotrexate if loss of efficacy is suspected.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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