Drug interactions
Bremelanotide + Digoxin
Severity: Moderate
Bremelanotide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may slow gastric emptying and thereby reduce the rate and extent of absorption of oral drugs taken at the same time. For digoxin, which has a narrow therapeutic index, a modest fall in exposure could reduce efficacy. The effect is theoretical and likely small in most patients.
What this interaction means in plain words
Bremelanotide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bremelanotide belongs to Genitourinary; Digoxin belongs to Cardiovascular.
Why it happens
Delayed gastric emptying from bremelanotide may reduce oral absorption of digoxin.
What to do
Monitor heart rate control or digoxin concentration if clinically indicated when bremelanotide is used regularly; use caution with other time-critical oral drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporine Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
- Bremelanotide + Tacrolimus Moderate
Frequently asked questions
Can I take Bremelanotide with Digoxin?
MediHelp rates the interaction as moderate. Bremelanotide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bremelanotide may slow gastric emptying and thereby reduce the rate and extent of absorption of oral drugs taken at the same time. For digoxin, which has a narrow therapeutic index, a modest fall in exposure could reduce efficacy. The effect is theoretical and likely small in most patients.
How serious is the interaction between Bremelanotide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate control or digoxin concentration if clinically indicated when bremelanotide is used regularly; use caution with other time-critical oral drugs.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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