Drug interactions
Bremelanotide + Bupropion-naltrexone
Severity: Moderate
Bremelanotide and Bupropion-naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide may slow gastric emptying and reduce absorption of oral drugs. Lower naltrexone exposure could compromise its effect, although the practical impact in the weight-management combination is uncertain.
What this interaction means in plain words
Bremelanotide and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bremelanotide belongs to Genitourinary; Bupropion-naltrexone belongs to Miscellaneous.
Why it happens
Delayed gastric emptying by bremelanotide may reduce the rate and extent of oral naltrexone absorption.
What to do
Monitor for reduced response to the combination product; avoid use if naltrexone is being used for alcohol or opioid dependence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bremelanotide and Bupropion-naltrexone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Bremelanotide
- Bremelanotide + Cyclosporine Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Naltrexone Moderate
- Bremelanotide + Procainamide Moderate
- Bremelanotide + Tacrolimus Moderate
Frequently asked questions
Can I take Bremelanotide with Bupropion-naltrexone?
MediHelp rates the interaction as moderate. Bremelanotide and Bupropion-naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bremelanotide may slow gastric emptying and reduce absorption of oral drugs. Lower naltrexone exposure could compromise its effect, although the practical impact in the weight-management combination is uncertain.
How serious is the interaction between Bremelanotide and Bupropion-naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to the combination product; avoid use if naltrexone is being used for alcohol or opioid dependence.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
