Drug interactions
Bremelanotide + Naltrexone
Severity: Moderate
Bremelanotide and Naltrexone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bremelanotide can slow gastric emptying and may reduce the rate and extent of absorption of oral drugs. For oral naltrexone used in alcohol or opioid dependence, reduced absorption could weaken opioid blockade and risk treatment failure.
What this interaction means in plain words
Bremelanotide and Naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bremelanotide belongs to Genitourinary; Naltrexone belongs to Musculoskeletal.
Why it happens
Delayed gastric emptying from bremelanotide may reduce absorption of oral naltrexone.
What to do
Avoid using bremelanotide with oral naltrexone prescribed for addiction treatment where possible, or consider an alternative such as extended-release injectable naltrexone. Monitor for signs of relapse or breakthrough craving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Naloxegol + Naltrexone Major
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
- Dronabinol + Naltrexone Minor
Other interactions of Bremelanotide
- Bremelanotide + Bupropion-naltrexone Moderate
- Bremelanotide + Cyclosporine Moderate
- Bremelanotide + Digoxin Moderate
- Bremelanotide + Disopyramide Moderate
- Bremelanotide + Procainamide Moderate
- Bremelanotide + Tacrolimus Moderate
Frequently asked questions
Can I take Bremelanotide with Naltrexone?
MediHelp rates the interaction as moderate. Bremelanotide and Naltrexone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bremelanotide can slow gastric emptying and may reduce the rate and extent of absorption of oral drugs. For oral naltrexone used in alcohol or opioid dependence, reduced absorption could weaken opioid blockade and risk treatment failure.
How serious is the interaction between Bremelanotide and Naltrexone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using bremelanotide with oral naltrexone prescribed for addiction treatment where possible, or consider an alternative such as extended-release injectable naltrexone. Monitor for signs of relapse or breakthrough craving.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naldemedine, Naloxegol, Lofexidine. The full list is on the Naltrexone page.
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